Nuclear factor-kappa-B/steroid hormone receptor interactions as a functional basis of anti-inflammatory action of steroids in reproductive organs.

Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism.

Nuclear factor kappa B (NF-kappa B) is an inducible transcription factor that positively regulates the expression of proimmune and proinflammatory genes, while glucocorticoids are potent suppressors of immune and inflammatory responses. NF-kappa B and the glucocorticoid receptor (GR) physically interact, resulting in repression of NF-kappa B transactivation. In transient cotransfection experime...

Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways.

Function of estrogen receptor (ER) in gene expression.

Estrogen (E2) plays significant roles in ligand target organs such as the reproductive organs, bone and the brain. This female steroid hormone is well known also to be deeply involved in cancer development in the reproductive organs. The majority of E2 actions are mediated through its nuclear estrogen receptor (ER). ERa and ER~ are members of the steroid/thyroid hormone nuclear receptor superfa...

P 139: Curcumin anti-Inflammatory Effect in Neuroinflammatory Disorders: Prospective and Challenges

Curcumin is a hydrophobic polyphenol and major bioactive component of turmeric with known anti-inflammatory, neurogenesis, antioxidant, and anti-carcinogenic effect. Curcumin antagonizes many steps in the inflammatory cascade, including Inhibition of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), activator protein-1 transcription and iNOS (induced Nitric oxide syn...

Modulation of Lipopolysaccharide Stimulated Nuclear Factor kappa B Mediated iNOS/NO Production by Bromelain in Rat Primary Microglial Cells

Background: Microglial cells act as the sentinel of the central nervous system .They are involved in neuroprotection but are highly implicated in neurodegeneration of the aging brain. When over-activated, microglia release pro-inflammatory factors, such as nitric oxide (NO) and cytokines, which are critical in eliciting neuroinflammatory responses associated with neurodegenerative diseases. Thi...